1/7/2024 0 Comments Dobutamine drip![]() Monitor ECG and BP continuously during administration.At any given dosage level, drug takes 10≢0 min to produce peak effects. Correct hypovolemia by administration of appropriate volume expanders prior to initiation of therapy.Metabolism: Metabolized in liver and other tissues by COMT. Use generally avoided mao inhibitors, tricyclic antidepressants potentiate pressor effectsuse with extreme caution. Interactions Drug: general anesthetics (especially cyclopropane and halothane) may sensitize myocardium to effects of catecholamines such as dobutamine and lead to serious arrhythmiasused with extreme caution beta-adrenergic blocking agents, e.g., metoprolol, propranolol, may make dobutamine ineffective in increasing cardiac output, but total peripheral resistance may increaseconcomitant Other: Nonspecific chest pain, shortness of breath. CV: Increased heart rate and BP, premature ventricular beats, palpitation, anginal pain. CNS: Headache, tremors, paresthesias, mild leg cramps, nervousness, fatigue (with overdosage). Refrigerate reconstituted solution at 2°≡5° C (36°≥9° F) for 48 h or store for 6 h at roomĪdverse Effects ( 1%) All: Generally dose related.Y-site: Acyclovir, aminophylline, sodium bicarbonate. INCOMPATIBILITIES Solution/additive: Sodium bicarbonate, aminophylline, bretylium, bumetanide, calcium chloride, calcium gluconate, diazepam, doxapram, digoxin, epinephrine, furosemide, heparin, insulin, magnesium sulfate, nitroprusside sodium, phenytoin, potassium chloride, potassium phosphate. Whenever possible, by measurements of cardiac output and central venous or pulmonary wedge pressures. IV infusion rate and duration of therapy are determined by heart rate, blood pressure, ectopic activity, urine output, and.Rate of infusion is determined by body weight and controlled by an infusion pump (preferred) or a microdrip IV infusion set.Use IV solutions within 24 h.ĪDMINISTER: Continuous:.Further dilute to a volume of at least 50 mL with D5W, NS, LR, D5/LR, or sodium lactate injection.Reconstitute by adding 10 mL sterile water for injection or D5W to 250-mg vial if not completely dissolved, add an additionalġ0 mL of diluent.Route & Dosage Cardiac DecompensationĪdult/ Child: IV 2.5≡0 mcg/kg/min (max: 40 mcg/kg/min), has been given for up to 72 h without decrease in effectiveness Preexisting hypertension, atrial fibrillation. Safe use during pregnancy (category C), lactation, children, or following acute MI is not established. History of hypersensitivity to other sympathomimetic amines, ventricular tachycardia, idiopathic hypertrophic subaortic stenosis. To augment cardiovascular function in children undergoing cardiac catheterization, stress thallium testing. (cardiogenic shock) resulting from either organic heart disease or from cardiac surgery. Inotropic support in short-term treatment of adults with cardiac decompensation due to depressed myocardial contractility In CHF or cardiogenic shock, increase in cardiac output enhances renal perfusion and increases renal output and renal sodium Has lower potential for precipitating arrhythmias than dopamine. Also increases conduction through AV node. Output and decreases pulmonary wedge pressure and total systemic vascular resistance with comparatively little or no effect Produces inotropic effect by acting on beta receptors and primarily on myocardial alpha-adrenergic receptors. DOBUTAMINE HYDROCHLORIDE DOBUTAMINE HYDROCHLORIDEĬlassifications: autonomic nervous system agent beta-adrenergic agonist catecholamine
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